BJPsych Articles:

Tyrer, P., Feruson, B., Hallstrom, C., et al (1996) A Controlled Trial of Dothiepin and Placebo in Treating Benzodiazepine Withdrawal Symptoms. British Journal of Psychiatry, 168, 457-461.

Conclusions Dothiepin (and by implication other tricyclic antidepressants) might have some value in reducing benzodiazepine withdrawal symptoms but does not aid drug withdrawal.


Baillie,J., Mattick, R.P. (1996) The Benzodiazepine Dependence Questionnaire: Development, Reliability and Validity. British Journal of Psychiatry, 169, 276-281.

Conclusion The BDEPQ was found to be a reliable and valid self-report instrument for the assessment of BZD dependence in samples approximating the general population of people using BZDs.



Database   EMBASE

Accession Number   2009227578

Authors   Hood S. O'Neil G. Hulse G.


  (Hood, Hulse) School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia.

  (O'Neil) Australian Medical Procedures Research Foundation, Perth, Australia.

  (Hood) School of Psychiatry and Clinical Neurosciences (M521), University of Western Australia, Perth, Australia. 

Country of Publication

  United Kingdom


  The role of flumazenil in the treatment of benzodiazepine dependence: Physiological and psychological profiles.


  Journal of Psychopharmacology.  23(4)(pp 401-409), 2009. Date of Publication: June 2009.


  SAGE Publications Ltd


  Two-related studies are presented here, detailing our early experience with benzodiazepine-dependent patients treated with a four-day flumazenil infusion using a novel delivery technique. Patients with long-term benzodiazepine dependence who attended the Australian Medical Procedures Research Foundation (AMPRF, Perth, Australia) for treatment were recruited for these studies. Self-reported psychological and physical symptoms, as well as objective vital signs data were collected at intervals before, during and 2 weeks postinfusion. Study A is a case series with cardiovascular measures; study B is an open trial that tracks the psychological profiles of 13 subjects. Withdrawal symptoms were tracked, however, the nature and severity of these symptoms differed between patients. No major complications or discomfort prompting study dropout was observed. Significant benzodiazepine abstinence occurred with this flumazenil infusion method despite high levels of initial dependence, comorbid substance use and comorbid psychiatric illness. Low-dose flumazenil infusion appears to be a safe and effective treatment resulting in withdrawal symptoms of lesser severity than any other cessation method currently available. Recommendations for future research are discussed. copyright 2009 British Association for Psychopharmacology.

ISSN   0269-8811

Publication Type   Journal: Article

Journal Name   Journal of Psychopharmacology

Volume   23

Issue Part  4

Page 401-409

Year of Publication   2009

Date of Publication  June 2009


RCPsych Literature Search BENZODIAZEPINES 2006

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Assessment of the consumption and consequences of zopiclone (Zimovane) among drug-takers in a

North East town Dr. Russell Newcombe Senior Researcher, Lifeline. Produced in September 2009